Leptin (a timadzi) ankalimbikitsa - zikutanthauza chiyani? Leptin - ndi timadzi machulukitsidwe: ntchito ndi udindo wake

Mozungulira 2011 World Health Organization, ofufuza ayamba kulabadira ngozi yomwe kunenepa. Kuyambira nthawi imeneyo, izo wayamba kale amagula zinthu zambiri mliri, ndi kunenepa kuti chimvele ngakhale ana. zaka zingapo m'mbuyomu, asayansi anapeza leptin - ndi timadzi kuti ndi udindo kumverera kwa satiety ndipo angagwiritsidwe ntchito pa matenda a matenda.

mbali zotsatira za kafukufuku parabiosis

Mbiri ya atulukira izi timadzi likugwirizana ndi kafukufuku wa sayansi American Hervey ankafuna njira parabiosis. Zimenezi ndi kwachilengedwenso mu m'galasi splicing nyama awiri ndipo nthawi zina atatu. Pa nthawi yomweyo iwo anakhazikitsa wamba mitsempha ya magazi ndi lymph. Research a mtundu umenewu zinali zofunika kuti kuphunzira zimene zimachitika pakati pa timadzi ndi spliced minofu.

Wasayansi anali ndi chidwi kufotokoza mokwanira ntchito zonse za ubongo imene imalamulira kutentha kwa. Nthawi zimachitika mu sayansi, pakati choncho mu njira ya kafukufuku satiety wake timadzi leptin anatulukira. Pofika mu 1998, nkhani imeneyi zonena za 600 nkhani.

Kodi ntchito ya leptin mu thupi chiyani?

Kumasulira a Chigiriki dzina lake limatanthauza "wochepa, ofooka." Komabe, mawu otsiriza a izo sizingakhoze adzatchedwa. Ndipotu, udindo wake mu thupi kwambiri. Leptin - ndi timadzi kumene kumachokera gulu lapadera zinthu otchedwa adipokines. Mosiyana ndi mahomoni ena, iwo amapangidwa si ziwalo dongosolo endocrine, ndi adipose minofu. Adipokines m'thupi ndi pazankhani ntchito. Mwachitsanzo, leptin amatha kupatsira mudziwe kuti ubongo imene imalamulira kutentha kwa mmene kwambiri kapena zochepa kuposa mafuta anali mu thupi pambuyo ingestion. Nawonso ubongo imene imalamulira kutentha nthawi kudya chakudya - ukuwonjezeka kapena amachepetsa njala.

Leptin ntchito sangathe saganizira. Imalimbikitsa kudya yimitsira, kumaonjezera njira thermogenesis, i.e. kumasulira mafuta mu mphamvu ndi mosemphanitsa. Leptin kumatanthauza kupanga dopamine. Mu wamkazi chamoyo leptin anakopa mokhazikika kuzungulira kusamba. Komanso bwino ntchito kwa dongosolo lonse wamkazi ubereki wonse. Komanso, peputayidi izi zimafunika utithandize chitetezo chokwanira.

Leptin ntchito mogwirizana ndi ubongo imene imalamulira kutentha kwa. Pamene munthu amadya chakudya, ndi ku ubongo imene imalamulira kutentha ndi amalandira chizindikiro amene amayambitsa maganizo chidzalo. Ubale wa leptin ndi dopamine anapeza asayansi osati kale. Tsopano pali maganizo kuti chisangalalo ndi zinthu zina kudya, pali chifukwa chosowa dopamine ndi leptin imodzi.

misinkhu Leptin ndi malamulo payekha

leptin mfundo akhoza kukhala osiyanasiyana malingana ndi kukhala m'gulu makamaka zaka. Komanso kuchuluka kwa leptin opangidwa zimatengera jenda. Isanafike isanayambike msinkhu anyamata ndi atsikana za yofanana leptin. Ndiye zinthu zimasintha kwambiri. Popeza nthawi zambiri akazi thupi minofu mafuta, amaudindo leptin ndi isanayambike msinkhu atsikana ndi apamwamba. Komanso pa chizindikiro ichi bwanji esitirojeni.

The zikuchokera timadzi wa

Leptin - ndi timadzi kuti mapulani ake ndi peputayidi. Pamafunikanso 167 zinthu - zatsalira kwa amino acid. Zambiri timadzi izi imatulutsidwa ndi maselo mafuta mwachindunji. Komabe, kuonjezera paminda ungatithandize zina maselo. Ndicho, nsengwa, mammary epithelium, chapamimba mucosa, chigoba minofu.

misinkhu apamwamba leptin ngati chinthu cha matenda mtsempha wamagazi

Komabe, milingo onse otsika ndi mkulu wa mahomoni onse ndi zoyipa pa thupi. N'chimodzimodzinso leptin. Timadzi akweza - chomwe chimatanthauza ndi mmene zingakhudze chiwerengero pa thupi? Choyamba, mpweya wambiri wa leptin chinthu chiopsezo cha matenda osiyanasiyana. Mwachitsanzo, gululi leptin amakwiya ponso minofu kotenga ndi mafunsidwe a salt zosiyanasiyana ziwiya magazi, imbaenda CHD.

Leptin ndi shuga

An vutoli wa leptin chikukhudzana ndi matenda ambiri. Zotsatirapo oopsa kulephera mu ntchito yake ndi shuga. matenda anapeza posachedwapa, madokotala, umanena pa timadzi leptin. Ndiyenso amabweretsa chiri, peputayidi mu nkhani iyi? Anthu athanzi, leptin kumaonjezera kuchuluka kwa linanena bungwe shuga ndi matupi awo. Komanso amachepetsa kaphatikizidwe wa insulin mu kapamba. Pamene thupi wambirimbiri leptin, kumakhaladi chifukwa cha kupoletsa ndalama yaikulu kwambiri insulin. Kumalimbitsa tilinazo thupi insulin ndi leptin. timadzi ndi wokwezeka pa anthu amene chibadwa predisposed kapena atengeke zinthu zina chiopsezo kuchititsa shuga.

Mogwirizana ndi timadzi wina peputayidi

Mmodzi wa chachikulu "bwanawe" wa leptin mu lamulo la makhalidwe kudya ndi "njala timadzi". Leptin ndi ghrelin (zotchedwa timadzi) kucheza ndi mzake ndi kuchita ntchito zosiyana. Ghrelin amachititsa kumva njala ndi kuletsedwa yomweyo pambuyo chakudya. Posachedwapa inali kudziŵika kuti peputayidi ichinso kumapangitsa kunenepa pamapeto pake. Monga amapangidwa zedi mkulu pa zinthu zopanikiza. N'chifukwa chake pambuyo kucheza yaitali ndikufuna chakudya.

Kodi kuchita zinthu zakudya leptin. Timadzi ndi kumverera kwa chidzalo

Mwatsoka, ambiri mafani zakudya ayenera zafotokozeredwa malamulo amenewa popanda ziyenera moyenera mavuto onse zotheka kwa thupi. Ambiri a zakudya ndi mankhwala ndi wotsikirapo mlingo wa mowa wa chakudya ndi mafuta kuwombola amene amatenga yogwira gawo leptin timadzi. Ndiyenso amabweretsa zimene zili kutsogolo kwa aliyense mtsikana kapena mzimayi amene mosaganizira anaganiza zoti akhale pa zakudya okhwima Mwachitsanzo, odziwika "boma la Russia?" Chiopsezo chachikulu amagwirizana ndi matenda kagayidwe kachakudya. Ndipotu, zakudya zimene amagwira kupereŵera kwambiri mowa chakudya. Komanso, pamene pafupifupi choletsedwa mafuta, komanso kungachititse kuti zosiyanasiyana matenda endocrine.

Ambiri ndamva kuti pambuyo chakudya kulemera angabwerenso, ndipo mpaka wamkulu. Ichi ndi chifukwa chakuti ubongo zambiri zochepa anayamba kuyankha leptin. M'mawu ena, pambuyo anachita izi kwa leptin hypothalamic amakhala kangapo wotsika. Posachedwapa, emaciated mkazi akali zonse kumverera njala chifukwa cha kupeza kulemera kwambiri. Komanso, ubongo analandira pa chiyambi cha zakudya zokwanira nambala ya chizindikiro cha pakutchulidwa "nthawi njala" adzalamulira amaika mphamvu zochepa ngati n'kotheka. Choncho, masewera ndi masewera olimbitsa thupi ndi zovuta - kapena zambiri ndi mtsikana poyamba kukhala moyo wongokhala.

Kodi pali lingaliro kwa chakudya?

Kumene, m'kati kuonda, mukhoza kutaya ndalama zambiri mafuta m'thupi, ndi nthawi yomweyo mu mwachilungamo nthawi yochepa. Komabe, mathithi ndi leptin. Timadzi akweza - zikutanthauza chiyani munthu amene kupita pa chakudya? Ambiri mwina, mlingo wake ali kwambiri adatchithisira mu sabata loyamba. Siyani ndi mafuta - koma chiyani tinganene ngati ubongo wotaya luso kumva njala ndi zonse mu mkhalidwe "mwadzidzidzi"? Pa kukana zotsatira kwa leptin zosavuta kunenepa mu masiku oyambirira chakudya.

Anthu amene amadwala wonenepa kapena kunenepa, ndi nthawi amakhala kovuta kuti kuonda. Ndipotu, matupi awo amasandulika saganizira leptin. Ndi chilichonse chakudya ayenera kudya kwambiri, chifukwa ubongo wawo kale pafupifupi samva kwa machulukitsidwe timadzi kuonetsetsa kuti thupi njala. Leptin - ndi timadzi machulukitsidwe - ikutha kukhala nawo iwo monga chonchi.

Njira bwino leptin ndi ghrelin

Njira yokha ya bwalo wankhanza - kuchita masewera olimbitsa thupi. Izi zidzathandiza kuti pang'onopang'ono kubwezeretsa hypothalamic leptin tilinazo. Nawonso njala timadzi ghrelin komanso akubwera ndi zabwinobwino. Kafukufuku wasonyeza kuti ngakhale theka la ora aerobic masewera olimbitsa thupi amathandiza kuchepetsa anthu ambiri ghrelin m'magazi. Choncho thupi kwambiri kumathandiza muchisiye mafuta owonjezera ndi kuchepetsa njala.

Kulamulira bwino leptin ndi ghrelin bwino m'thupi, ofufuza kupereka malangizo otsatirawa. Choyamba, muyenera kutsatira tsiku chizolowezi okhwima - timakagona padziko teni koloko usiku ndi kudzuka asanu m'mawa. Kachiwiri, kufunika kuthana ndi kulipiritsa mmawa uliwonse, kapena Zochita ena. Ngakhale masewera olimbitsa thupi laling'ono pa chopanda kanthu m'mimba, monga Ofufuza apeza kuti amathandiza kusintha kudziwa insulin komanso shuga. Ndipo izi - njira yabwino kupewa matenda a shuga.